MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma

MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma

The prognostic implications of miR-21, miR-17-92 and miR-155 were evaluated in diffuse large B-cell lymphoma (DLBCL) patients, and novel mechanism by which miR-21 contributes to the oncogenesis of DLBCL by regulating FOXO1 and PI3K/AKT/mTOR pathway was investigated. The expressions of miR-21, miR-17...

Full description

Bibliographic Details
Main Authors:	Go, Heounjeong, Jang, Ji-Young, Kim, Pil-Jong, Kim, Young-Goo, Nam, Soo Jeong, Paik, Jin Ho, Kim, Tae Min, Heo, Dae Seog, Kim, Chul-Woo, Jeon, Yoon Kyung
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558134/

Similar Items

RUNX2 Plays An Oncogenic Role in Esophageal Carcinoma by Activating the PI3K/AKT and ERK Signaling Pathways
by: Huibin Lu, et al.
Published: (2018-08-01)

Tempol Attenuates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction: The Role of PI3K-Akt-FoxO3a Signaling
by: Yoon, Hye Eun, et al.
Published: (2014)

Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas
by: Paik, Jin Ho, et al.
Published: (2014)

Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats
by: JUNG, SUN-YOUNG, et al.
Published: (2014)

Redox-Sensitive Up-Regulation of eNOS by Purple Grape Juice in Endothelial Cells: Role of PI3-Kinase/Akt, p38 MAPK, JNK, FoxO1 and FoxO3a
by: Alhosin, Mahmoud, et al.
Published: (2013)

Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition
by: Lee, Jin-Kwan, et al.
Published: (2016)

Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways
by: Kim, Gi Dae
Published: (2014)

Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1
by: Kim, Wook Youn, et al.
Published: (2014)

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation
by: Smit, L., et al.
Published: (2015)

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation
by: Smit, Linda, et al.
Published: (2015)

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation
by: Cohen, Shenhav, et al.
Published: (2014)

Hypoxia Enhances Chondrogenesis and Prevents Terminal Differentiation through PI3K/Akt/FoxO Dependent Anti-Apoptotic Effect
by: Lee, Hsieh-Hsing, et al.
Published: (2013)

Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines
by: Gwak, Ho-Shin, et al.
Published: (2012)

Nrf2 Negatively Regulates Melanogenesis by Modulating PI3K/Akt Signaling
by: Shin, Jung-Min, et al.
Published: (2014)

Suppression of FoxO6 by lipopolysaccharide in aged rat liver
by: Kim, Dae Hyun, et al.
Published: (2015)

SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma
by: Yu-Feng Yang, et al.
Published: (2018-08-01)

Novel PI3K/Akt Inhibitors Screened by the Cytoprotective Function of Human Immunodeficiency Virus Type 1 Tat
by: Kim, Yuri, et al.
Published: (2011)

Benign Indolent CD56-Positive NK-Cell Lymphoproliferative Lesion Involving Gastrointestinal Tract in an Adolescent
by: Koh, Jaemoon, et al.
Published: (2014)

Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications
by: Park, See-Hyoung, et al.
Published: (2015)

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
by: Lu, Mingjian, et al.
Published: (2012)

The role of AKT and FOXO3 in preventing ovarian toxicity induced by cyclophosphamide.
by: Bao-Fang Zhang, et al.

Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer
by: Das, T P, et al.
Published: (2016)

β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway
by: Yu, Hai Yang, et al.
Published: (2014)

The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the β-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt
by: Regmi, Sushil C., et al.
Published: (2015)

Iron deficient erythropoiesis might play key role in development of anemia in cancer patients
by: Park, Silvia, et al.
Published: (2015)

Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression
by: Amente, Stefano, et al.
Published: (2011)

Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression
by: Amente, Stefano, et al.
Published: (2014)

The PI3K/AKT Pathway and FOXO3a Transcription Factor Mediate High Glucose-Induced Apoptosis in Neonatal Rat Ventricular Myocytes
by: Bao, Weiguo, et al.
Published: (2014)

Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway
by: Yang, Cheng, et al.
Published: (2015)

MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system
by: Kim, Sehui, et al.
Published: (2016)

Mycobacterial Heparin-binding Hemagglutinin Antigen Activates Inflammatory Responses through PI3-K/Akt, NF-κB, and MAPK Pathways
by: Kim, Ki-Hye, et al.
Published: (2011)

Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway
by: Tarassishin, Leonid, et al.
Published: (2011)

Invasion of the great vessels or atrium predicts worse prognosis in thymic carcinoma
by: Eom, Keun-Yong, et al.
Published: (2013)

MicroRNA Dysregulation in Liver and Pancreas of CMP-Neu5Ac Hydroxylase Null Mice Disrupts Insulin/PI3K-AKT Signaling
by: Kwon, Deug-Nam, et al.
Published: (2014)

Role of PI3K/Akt signaling in memory CD8 T cell differentiation
by: Kim, Eui Ho, et al.
Published: (2013)

Ribonuclease 5 facilitates corneal endothelial wound healing via activation of PI3-kinase/Akt pathway
by: Kim, Kyoung Woo, et al.
Published: (2016)

Arctigenin Increases Hemeoxygenase-1 Gene Expression by Modulating PI3K/AKT Signaling Pathway in Rat Primary Astrocytes
by: Jeong, Yeon-Hui, et al.
Published: (2014)

Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt
by: Cheol Park, et al.
Published: (2018-08-01)

Activation of the Renal PI3K/Akt/mTOR Signaling Pathway in a DOCA-Salt Model of Hypertension
by: Ma, Seong Kwon, et al.
Published: (2012)

ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells
by: Baik, Seung Hyun, et al.
Published: (2016)