Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline

In searching for small-molecule compounds that inhibit proliferation and survival of diffuse large B-cell lymphoma (DLBCL) cells and may, therefore, be exploited as potential therapeutic agents for this disease, we identified the commonly used and well-tolerated antibiotic doxycycline as a strong ca...

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Bibliographic Details
Main Authors: Pulvino, Mary, Chen, Luojing, Oleksyn, David, Li, Jing, Compitello, George, Rossi, Randy, Spence, Stephen, Balakrishnan, Vijaya, Jordan, Craig, Poligone, Brian, Casulo, Carla, Burack, Richard, Shapiro, Joel L., Bernstein, Steven, Friedberg, Jonathan W., Deshaies, Raymond J., Land, Hartmut, Zhao, Jiyong
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558116/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558116/

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