Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?

Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?

The mechanisms underlying seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe seizures in order to analyze their role in seizure termination. Twenty-two seizures from 10 patients with drug-re...

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Main Authors: Evangelista, Elisa, Bénar, Christian, Bonini, Francesca, Carron, Romain, Colombet, Bruno, Régis, Jean, Bartolomei, Fabrice
Format: Online
Language:English
Published: Frontiers Media S.A. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555023/
id pubmed-4555023
recordtype oai_dc
spelling pubmed-45550232015-09-18 Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination? Evangelista, Elisa Bénar, Christian Bonini, Francesca Carron, Romain Colombet, Bruno Régis, Jean Bartolomei, Fabrice Neuroscience The mechanisms underlying seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe seizures in order to analyze their role in seizure termination. Twenty-two seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thalamo-mesio temporal index at the onset and the end of seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed seizures and thalamic synchronization index was significantly more elevated at the end of seizure than at the onset. The global synchronization index at the end of seizure negatively correlated with seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with seizure duration. Six seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to seizure termination via modulation of cortical synchronization. In the subgroup of SWP seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to seizure termination. Frontiers Media S.A. 2015-09-01 /pmc/articles/PMC4555023/ /pubmed/26388834 http://dx.doi.org/10.3389/fneur.2015.00192 Text en Copyright © 2015 Evangelista, Bénar, Bonini, Carron, Colombet, Régis and Bartolomei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Evangelista, Elisa
Bénar, Christian
Bonini, Francesca
Carron, Romain
Colombet, Bruno
Régis, Jean
Bartolomei, Fabrice
spellingShingle Evangelista, Elisa
Bénar, Christian
Bonini, Francesca
Carron, Romain
Colombet, Bruno
Régis, Jean
Bartolomei, Fabrice
Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
author_facet Evangelista, Elisa
Bénar, Christian
Bonini, Francesca
Carron, Romain
Colombet, Bruno
Régis, Jean
Bartolomei, Fabrice
author_sort Evangelista, Elisa
title Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
title_short Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
title_full Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
title_fullStr Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
title_full_unstemmed Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
title_sort does the thalamo-cortical synchrony play a role in seizure termination?
description The mechanisms underlying seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe seizures in order to analyze their role in seizure termination. Twenty-two seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thalamo-mesio temporal index at the onset and the end of seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed seizures and thalamic synchronization index was significantly more elevated at the end of seizure than at the onset. The global synchronization index at the end of seizure negatively correlated with seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with seizure duration. Six seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to seizure termination via modulation of cortical synchronization. In the subgroup of SWP seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to seizure termination.
publisher Frontiers Media S.A.
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555023/
_version_ 1613470993933664256

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