Spray-dried powders enhance vaginal siRNA delivery by potentially modulating the mucus molecular sieve structure
Vaginal small interfering RNA (siRNA) delivery provides a promising strategy for the prevention and treatment of vaginal diseases. However, the densely cross-linked mucus layer on the vaginal wall severely restricts nanoparticle-mediated siRNA delivery to the vaginal epithelium. In order to overcome...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Dove Medical Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554414/ |