International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs
Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in par...
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BioMed Central
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552344/ |
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pubmed-45523442015-08-29 International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs Hülsmeyer, Velia-Isabel Fischer, Andrea Mandigers, Paul J.J. DeRisio, Luisa Berendt, Mette Rusbridge, Clare Bhatti, Sofie F.M. Pakozdy, Akos Patterson, Edward E. Platt, Simon Packer, Rowena M.A. Volk, Holger A. Correspondence Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted. BioMed Central 2015-08-28 /pmc/articles/PMC4552344/ /pubmed/26316206 http://dx.doi.org/10.1186/s12917-015-0463-0 Text en © Hülsmeyer et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Hülsmeyer, Velia-Isabel Fischer, Andrea Mandigers, Paul J.J. DeRisio, Luisa Berendt, Mette Rusbridge, Clare Bhatti, Sofie F.M. Pakozdy, Akos Patterson, Edward E. Platt, Simon Packer, Rowena M.A. Volk, Holger A. |
| spellingShingle |
Hülsmeyer, Velia-Isabel Fischer, Andrea Mandigers, Paul J.J. DeRisio, Luisa Berendt, Mette Rusbridge, Clare Bhatti, Sofie F.M. Pakozdy, Akos Patterson, Edward E. Platt, Simon Packer, Rowena M.A. Volk, Holger A. International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs |
| author_facet |
Hülsmeyer, Velia-Isabel Fischer, Andrea Mandigers, Paul J.J. DeRisio, Luisa Berendt, Mette Rusbridge, Clare Bhatti, Sofie F.M. Pakozdy, Akos Patterson, Edward E. Platt, Simon Packer, Rowena M.A. Volk, Holger A. |
| author_sort |
Hülsmeyer, Velia-Isabel |
| title |
International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs |
| title_short |
International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs |
| title_full |
International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs |
| title_fullStr |
International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs |
| title_full_unstemmed |
International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs |
| title_sort |
international veterinary epilepsy task force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs |
| description |
Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted. |
| publisher |
BioMed Central |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552344/ |
| _version_ |
1613470015725502464 |