Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

Compound screening for altered nuclear phenotypes identifies several promiscuous kinase inhibitors that trigger progression of senescence during a polyploid G1. Their common target is AURKB. More-specific inhibition of AURKB phenocopies these compounds, demonstrating a causative role for AURKB defec...

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Bibliographic Details
Main Authors: Sadaie, Mahito, Dillon, Christian, Narita, Masashi, Young, Andrew R. J., Cairney, Claire J., Godwin, Lauren S., Torrance, Christopher J., Bennett, Dorothy C., Keith, W. Nicol
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551313/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551313/

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