A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease

We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-n...

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Main Authors:	Ohno, Kyotaro, Sato, Yasuharu, Ohshima, Koh-ichi, Takata, Katsuyoshi, Miyata-Takata, Tomoko, Takeuchi, Mai, Gion, Yuka, Tachibana, Tomoyasu, Orita, Yorihisa, Ito, Toshihiro, Swerdlow, Steven H., Yoshino, Tadashi
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550912/

id	pubmed-4550912
recordtype	oai_dc
spelling	pubmed-45509122015-09-04 A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease Ohno, Kyotaro Sato, Yasuharu Ohshima, Koh-ichi Takata, Katsuyoshi Miyata-Takata, Tomoko Takeuchi, Mai Gion, Yuka Tachibana, Tomoyasu Orita, Yorihisa Ito, Toshihiro Swerdlow, Steven H. Yoshino, Tadashi Article We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p < 0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis. Nature Publishing Group 2015-08-27 /pmc/articles/PMC4550912/ /pubmed/26311608 http://dx.doi.org/10.1038/srep13539 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ohno, Kyotaro Sato, Yasuharu Ohshima, Koh-ichi Takata, Katsuyoshi Miyata-Takata, Tomoko Takeuchi, Mai Gion, Yuka Tachibana, Tomoyasu Orita, Yorihisa Ito, Toshihiro Swerdlow, Steven H. Yoshino, Tadashi
spellingShingle	Ohno, Kyotaro Sato, Yasuharu Ohshima, Koh-ichi Takata, Katsuyoshi Miyata-Takata, Tomoko Takeuchi, Mai Gion, Yuka Tachibana, Tomoyasu Orita, Yorihisa Ito, Toshihiro Swerdlow, Steven H. Yoshino, Tadashi A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease
author_facet	Ohno, Kyotaro Sato, Yasuharu Ohshima, Koh-ichi Takata, Katsuyoshi Miyata-Takata, Tomoko Takeuchi, Mai Gion, Yuka Tachibana, Tomoyasu Orita, Yorihisa Ito, Toshihiro Swerdlow, Steven H. Yoshino, Tadashi
author_sort	Ohno, Kyotaro
title	A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease
title_short	A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease
title_full	A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease
title_fullStr	A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease
title_full_unstemmed	A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease
title_sort	subset of ocular adnexal marginal zone lymphomas may arise in association with igg4-related disease
description	We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p < 0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550912/
_version_	1613469540046340096

A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease

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