Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential

Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential

Activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 and heat-shock protein 90/heat-shock factor-1 signal-transduction pathways plays a central role in combatting cellular oxidative damage and related endoplasmic reticulum stress. Electrophilic compounds...

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Bibliographic Details
Main Authors: Satoh, Takumi, Stalder, Romain, McKercher, Scott R., Williamson, Robert E., Roth, Gregory P., Lipton, Stuart A.
Format: Online
Language:English
Published: SAGE Publications 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550314/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550314/

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