Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design

Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority. Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro...

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Bibliographic Details
Main Authors: Zhu, Qinchang, Bang, Tran Hai, Ohnuki, Koichiro, Sawai, Takashi, Sawai, Ken, Shimizu, Kuniyoshi
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549708/