Rational Design of Highly Potent and Slow-Binding Cytochrome bc1 Inhibitor as Fungicide by Computational Substitution Optimization

Rational Design of Highly Potent and Slow-Binding Cytochrome bc1 Inhibitor as Fungicide by Computational Substitution Optimization

Hit to lead (H2L) optimization is a key step for drug and agrochemical discovery. A critical challenge for H2L optimization is the low efficiency due to the lack of predictive method with high accuracy. We described a new computational method called Computational Substitution Optimization (CSO) that...

Full description

Bibliographic Details
Main Authors: Hao, Ge-Fei, Yang, Sheng-Gang, Huang, Wei, Wang, Le, Shen, Yan-Qing, Tu, Wen-Long, Li, Hui, Huang, Li-Shar, Wu, Jia-Wei, Berry, Edward A., Yang, Guang-Fu
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549706/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549706/

Similar Items