Bile acids induce hepatic differentiation of mesenchymal stem cells

Mesenchymal stem cells (MSC) have the potential to differentiate into multiple cell lineages and their therapeutic potential has become obvious. In the liver, MSC are represented by stellate cells which have the potential to differentiate into hepatocytes after stimulation with growth factors. Since...

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Main Authors:	Sawitza, Iris, Kordes, Claus, Götze, Silke, Herebian, Diran, Häussinger, Dieter
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548444/

id	pubmed-4548444
recordtype	oai_dc
spelling	pubmed-45484442015-08-26 Bile acids induce hepatic differentiation of mesenchymal stem cells Sawitza, Iris Kordes, Claus Götze, Silke Herebian, Diran Häussinger, Dieter Article Mesenchymal stem cells (MSC) have the potential to differentiate into multiple cell lineages and their therapeutic potential has become obvious. In the liver, MSC are represented by stellate cells which have the potential to differentiate into hepatocytes after stimulation with growth factors. Since bile acids can promote liver regeneration, their influence on liver-resident and bone marrow-derived MSC was investigated. Physiological concentrations of bile acids such as tauroursodeoxycholic acid were able to initiate hepatic differentiation of MSC via the farnesoid X receptor and transmembrane G-protein-coupled bile acid receptor 5 as investigated with knockout mice. Notch, hedgehog, transforming growth factor-β/bone morphogenic protein family and non-canonical Wnt signalling were also essential for bile acid-mediated differentiation, whereas β-catenin-dependent Wnt signalling was able to attenuate this process. Our findings reveal bile acid-mediated signalling as an alternative way to induce hepatic differentiaion of stem cells and highlight bile acids as important signalling molecules during liver regeneration. Nature Publishing Group 2015-08-25 /pmc/articles/PMC4548444/ /pubmed/26304833 http://dx.doi.org/10.1038/srep13320 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sawitza, Iris Kordes, Claus Götze, Silke Herebian, Diran Häussinger, Dieter
spellingShingle	Sawitza, Iris Kordes, Claus Götze, Silke Herebian, Diran Häussinger, Dieter Bile acids induce hepatic differentiation of mesenchymal stem cells
author_facet	Sawitza, Iris Kordes, Claus Götze, Silke Herebian, Diran Häussinger, Dieter
author_sort	Sawitza, Iris
title	Bile acids induce hepatic differentiation of mesenchymal stem cells
title_short	Bile acids induce hepatic differentiation of mesenchymal stem cells
title_full	Bile acids induce hepatic differentiation of mesenchymal stem cells
title_fullStr	Bile acids induce hepatic differentiation of mesenchymal stem cells
title_full_unstemmed	Bile acids induce hepatic differentiation of mesenchymal stem cells
title_sort	bile acids induce hepatic differentiation of mesenchymal stem cells
description	Mesenchymal stem cells (MSC) have the potential to differentiate into multiple cell lineages and their therapeutic potential has become obvious. In the liver, MSC are represented by stellate cells which have the potential to differentiate into hepatocytes after stimulation with growth factors. Since bile acids can promote liver regeneration, their influence on liver-resident and bone marrow-derived MSC was investigated. Physiological concentrations of bile acids such as tauroursodeoxycholic acid were able to initiate hepatic differentiation of MSC via the farnesoid X receptor and transmembrane G-protein-coupled bile acid receptor 5 as investigated with knockout mice. Notch, hedgehog, transforming growth factor-β/bone morphogenic protein family and non-canonical Wnt signalling were also essential for bile acid-mediated differentiation, whereas β-catenin-dependent Wnt signalling was able to attenuate this process. Our findings reveal bile acid-mediated signalling as an alternative way to induce hepatic differentiaion of stem cells and highlight bile acids as important signalling molecules during liver regeneration.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548444/
_version_	1613263424518619136

Bile acids induce hepatic differentiation of mesenchymal stem cells

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