The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage
Spermatogonial stem cells (SSCs) undergo self-renewal divisions to provide the foundation for spermatogenesis. Although Rb1 deficiency is reportedly essential for SSC self-renewal, its mechanism has remained unknown. Here we report that Rb1 is critical for cell cycle progression and protection of S...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Society for Reproduction and Development
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547988/ |