Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes

Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes

GAD autoantibodies (GADAs) are sensitive markers of islet autoimmunity and type 1 diabetes. They form the basis of robust prediction models and are widely used for the recruitment of subjects at high risk of type 1 diabetes to prevention trials. However, GADAs are also found in many individuals at l...

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Bibliographic Details
Main Authors: Williams, Alistair J.K., Lampasona, Vito, Schlosser, Michael, Mueller, Patricia W., Pittman, David L., Winter, William E., Akolkar, Beena, Wyatt, Rebecca, Brigatti, Cristina, Krause, Stephanie, Achenbach, Peter
Format: Online
Language:English
Published: American Diabetes Association 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542444/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542444/

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