The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interfer...

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Bibliographic Details
Main Authors: Mannion, Niamh M., Greenwood, Sam M., Young, Robert, Cox, Sarah, Brindle, James, Read, David, Nellåker, Christoffer, Vesely, Cornelia, Ponting, Chris P., McLaughlin, Paul J., Jantsch, Michael F., Dorin, Julia, Adams, Ian R., Scadden, A.D.J., Öhman, Marie, Keegan, Liam P., O’Connell, Mary A.
Format: Online
Language:English
Published: Cell Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542304/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542304/

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