Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases
Vancomycin resistance in Gram-positive bacteria results from the replacement of the d-alanyl–d-alanine target of peptidoglycan precursors with d-alanyl–d-lactate or d-alanyl–d-serine (d-Ala-d-Ser), to which vancomycin has low binding affinity. VanT is one of the proteins required for the production...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Society of Microbiology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542195/ |