Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy

Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy

Diabetic neuropathy (DNP), afflicting sensory and motor nerve fibers, is a major complication in diabetes. The underlying cellular mechanisms of axon degeneration are poorly understood. IGFBP5, an inhibitory binding protein for insulin-like growth factor 1 (IGF1) is highly up-regulated in nerve biop...

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Bibliographic Details
Main Authors: Simon, Christian M., Rauskolb, Stefanie, Gunnersen, Jennifer M., Holtmann, Bettina, Drepper, Carsten, Dombert, Benjamin, Braga, Massimiliano, Wiese, Stefan, Jablonka, Sibylle, Pühringer, Dirk, Zielasek, Jürgen, Hoeflich, Andreas, Silani, Vincenzo, Wolf, Eckhard, Kneitz, Susanne, Sommer, Claudia, Toyka, Klaus V., Sendtner, Michael
Format: Online
Language:English
Published: Springer Berlin Heidelberg 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541707/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541707/

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