Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction

Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction

Human dynactin-associated protein (dynAP) is a transmembrane protein that promotes AktSer473 phosphorylation. Here, we report the oncogenic properties of dynAP. In contrast to control NIH3T3 cells expressing LacZ (NIH3T3LacZ), NIH3T3dynAP cells vigorously formed foci in two-dimensional culture, colo...

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Bibliographic Details
Main Authors: Kunoh, Tatsuki, Wang, Weixiang, Kobayashi, Hiroaki, Matsuzaki, Daisuke, Togo, Yuki, Tokuyama, Masahiro, Hosoi, Miho, Koseki, Koichi, Wada, Shu-ichi, Nagai, Nobuo, Nakamura, Toshinobu, Nomura, Shintaro, Hasegawa, Makoto, Sasaki, Ryuzo, Mizukami, Tamio
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540312/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540312/

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