UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

HSP90 inhibition represents a promising route to cancer therapy, taking advantage of cancer cell-inherent proteotoxic stress. The HSP90-inhibitor ganetespib showed benefit in advanced clinical trials. This raises the need to identify the molecular determinants of treatment response. We tested the ef...

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Bibliographic Details
Main Authors: Landmann, H, Proia, D A, He, S, Ogawa, L S, Kramer, F, Beißbarth, T, Grade, M, Gaedcke, J, Ghadimi, M, Moll, U, Dobbelstein, M
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540199/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540199/

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