Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis

Photoreceptor outer segment (POS) phagosomes associate with the kinesin light chain 1 (KLC1) and move bidirectionally along microtubules in retinal pigment epithelium cells; lack of KLC1 results in impaired POS phagosome motility and degradation and, in aged mice, pathogenesis resembling age-related...

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Bibliographic Details
Main Authors: Jiang, Mei, Esteve-Rudd, Julian, Lopes, Vanda S., Diemer, Tanja, Lillo, Concepción, Rump, Agrani, Williams, David S.
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539993/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539993/

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