Alginate as a protease inhibitor in vitro and in a model gut system; selective inhibition of pepsin but not trypsin

•Alginate inhibits proteolytic activity of pepsin but not trypsin.•Level of pepsin inhibition correlates with alginate F[M].•An in vitro model gut system was used to model alginate inhibition of proteolysis.•Proteolysis inhibited in gastric phase of digestion, but not small intestinal phase.•pH depe...

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Bibliographic Details
Main Authors: Chater, Peter Ian, Wilcox, Mathew D., Brownlee, Iain A., Pearson, Jeffrey P.
Format: Online
Language:English
Published: Elsevier Applied Science Publishers 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539341/