Linking two DNA duplexes with a rigid linker for DNA nanotechnology

DNA has recently emerged as a promising material for the construction of nanosized architectures. Chemically modified DNA has been suggested to be an important component of such architectural building blocks. We have designed and synthesized a novel H-shaped DNA oligonucleotide dimer that is cross-l...

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Main Authors:	Tashiro, Ryu, Iwamoto, Masahiro, Morinaga, Hironobu, Emura, Tomoko, Hidaka, Kumi, Endo, Masayuki, Sugiyama, Hiroshi
Format:	Online
Language:	English
Published:	Oxford University Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538841/

id	pubmed-4538841
recordtype	oai_dc
spelling	pubmed-45388412015-08-18 Linking two DNA duplexes with a rigid linker for DNA nanotechnology Tashiro, Ryu Iwamoto, Masahiro Morinaga, Hironobu Emura, Tomoko Hidaka, Kumi Endo, Masayuki Sugiyama, Hiroshi Chemical Biology and Nucleic Acid Chemistry DNA has recently emerged as a promising material for the construction of nanosized architectures. Chemically modified DNA has been suggested to be an important component of such architectural building blocks. We have designed and synthesized a novel H-shaped DNA oligonucleotide dimer that is cross-linked with a structurally rigid linker composed of phenylene and ethynylene groups. A rotatable DNA unit was constructed through the self-assembly of this H-shaped DNA component and two complementary DNA oligonucleotides. In addition to the rotatable unit, a locked DNA unit containing two H-shaped DNA components was also constructed. As an example of an extended locked structure, a hexagonal DNA origami dimer and oligomer were constructed by using H-shaped DNA as linkers. Oxford University Press 2015-08-18 2015-06-30 /pmc/articles/PMC4538841/ /pubmed/26130712 http://dx.doi.org/10.1093/nar/gkv662 Text en © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tashiro, Ryu Iwamoto, Masahiro Morinaga, Hironobu Emura, Tomoko Hidaka, Kumi Endo, Masayuki Sugiyama, Hiroshi
spellingShingle	Tashiro, Ryu Iwamoto, Masahiro Morinaga, Hironobu Emura, Tomoko Hidaka, Kumi Endo, Masayuki Sugiyama, Hiroshi Linking two DNA duplexes with a rigid linker for DNA nanotechnology
author_facet	Tashiro, Ryu Iwamoto, Masahiro Morinaga, Hironobu Emura, Tomoko Hidaka, Kumi Endo, Masayuki Sugiyama, Hiroshi
author_sort	Tashiro, Ryu
title	Linking two DNA duplexes with a rigid linker for DNA nanotechnology
title_short	Linking two DNA duplexes with a rigid linker for DNA nanotechnology
title_full	Linking two DNA duplexes with a rigid linker for DNA nanotechnology
title_fullStr	Linking two DNA duplexes with a rigid linker for DNA nanotechnology
title_full_unstemmed	Linking two DNA duplexes with a rigid linker for DNA nanotechnology
title_sort	linking two dna duplexes with a rigid linker for dna nanotechnology
description	DNA has recently emerged as a promising material for the construction of nanosized architectures. Chemically modified DNA has been suggested to be an important component of such architectural building blocks. We have designed and synthesized a novel H-shaped DNA oligonucleotide dimer that is cross-linked with a structurally rigid linker composed of phenylene and ethynylene groups. A rotatable DNA unit was constructed through the self-assembly of this H-shaped DNA component and two complementary DNA oligonucleotides. In addition to the rotatable unit, a locked DNA unit containing two H-shaped DNA components was also constructed. As an example of an extended locked structure, a hexagonal DNA origami dimer and oligomer were constructed by using H-shaped DNA as linkers.
publisher	Oxford University Press
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538841/
_version_	1613260424083406848

Linking two DNA duplexes with a rigid linker for DNA nanotechnology

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