PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia

The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resistance in T-ALL, and patients harboring mutations in the PI3K negative regulator PTEN may be at increas...

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Bibliographic Details
Main Authors: Silveira, André Bortolini, Laranjeira, Angelo Brunelli Albertoni, Rodrigues, Gisele Olinto Libanio, Leal, Paulo César, Cardoso, Bruno António, Barata, João Taborda, Yunes, Rosendo Augusto, Zanchin, Nilson Ivo Tonin, Brandalise, Sílvia Regina, Yunes, José Andrés
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537002/

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