High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*

High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*

The 24-hour urinary C-peptide excretion (UCPR) is a useful means of estimating total daily insulin secretion. To evaluate the daily insulin secretion rate in non-insulin dependent diabetes mellitus (NIDDM), we measured UCPR in 22 patients with NIDDM and 18 normal subjects. The mean (±SD) UCPR in the...

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Main Authors: Chung, Young Hwan, Park, Kyong Soo, Lee, Ki Up, Kim, Seong Yeon, Lee, Hong Kyu, Min, Hun Ki
Format: Online
Language:English
Published: Korean Association of Internal Medicine 1986
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536715/
id pubmed-4536715
recordtype oai_dc
spelling pubmed-45367152015-10-02 High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus* Chung, Young Hwan Park, Kyong Soo Lee, Ki Up Kim, Seong Yeon Lee, Hong Kyu Min, Hun Ki Original Article The 24-hour urinary C-peptide excretion (UCPR) is a useful means of estimating total daily insulin secretion. To evaluate the daily insulin secretion rate in non-insulin dependent diabetes mellitus (NIDDM), we measured UCPR in 22 patients with NIDDM and 18 normal subjects. The mean (±SD) UCPR in the patients with NIDDM was 115.4±40.2 ug/day and that in normal subjects was 56.7±22.0 ug/day respectively with significantly higher values in the patients with NIDDM (P<0.0001). UCPR was positively correlated with body fat mass determined by measurement of skin fold thickness in both groups [r=0.51 in patients with NIDDM (n=22; p<0.02) and r=0.55 in normal subjects (n=18; p<0.02)], and was higher in NIDDM patients, even with the same degree of fat mass. There was no significant correlation between UCPR and body muscle mass both in the patients with NIDDM and normal subjects [r=0.16 in patients with NIDDM (n=22; p>0.1) and r=0.16 in normal subjects (n=18; p>0.1)]. This result suggested that the total daily insulin secretion rate in NIDDM be increased to compensate insulin resistance, especially that induced by adipose tissues. Korean Association of Internal Medicine 1986-07 /pmc/articles/PMC4536715/ /pubmed/3154612 http://dx.doi.org/10.3904/kjim.1986.1.2.172 Text en Copyright © 1986 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Chung, Young Hwan
Park, Kyong Soo
Lee, Ki Up
Kim, Seong Yeon
Lee, Hong Kyu
Min, Hun Ki
spellingShingle Chung, Young Hwan
Park, Kyong Soo
Lee, Ki Up
Kim, Seong Yeon
Lee, Hong Kyu
Min, Hun Ki
High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*
author_facet Chung, Young Hwan
Park, Kyong Soo
Lee, Ki Up
Kim, Seong Yeon
Lee, Hong Kyu
Min, Hun Ki
author_sort Chung, Young Hwan
title High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*
title_short High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*
title_full High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*
title_fullStr High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*
title_full_unstemmed High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus*
title_sort high 24-hour urinary c-peptide excretion in non-insulin dependent diabetes mellitus*
description The 24-hour urinary C-peptide excretion (UCPR) is a useful means of estimating total daily insulin secretion. To evaluate the daily insulin secretion rate in non-insulin dependent diabetes mellitus (NIDDM), we measured UCPR in 22 patients with NIDDM and 18 normal subjects. The mean (±SD) UCPR in the patients with NIDDM was 115.4±40.2 ug/day and that in normal subjects was 56.7±22.0 ug/day respectively with significantly higher values in the patients with NIDDM (P<0.0001). UCPR was positively correlated with body fat mass determined by measurement of skin fold thickness in both groups [r=0.51 in patients with NIDDM (n=22; p<0.02) and r=0.55 in normal subjects (n=18; p<0.02)], and was higher in NIDDM patients, even with the same degree of fat mass. There was no significant correlation between UCPR and body muscle mass both in the patients with NIDDM and normal subjects [r=0.16 in patients with NIDDM (n=22; p>0.1) and r=0.16 in normal subjects (n=18; p>0.1)]. This result suggested that the total daily insulin secretion rate in NIDDM be increased to compensate insulin resistance, especially that induced by adipose tissues.
publisher Korean Association of Internal Medicine
publishDate 1986
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536715/
_version_ 1613259750192971776

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