Transcriptomic profiling of trichloroethylene exposure in male mouse liver

Transcriptomic profiling of trichloroethylene exposure in male mouse liver

Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation chang...

Full description

Bibliographic Details
Main Authors: Jiang, Yan, Chen, Jiahong, Tong, Jian, Chen, Tao
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535943/
id pubmed-4535943
recordtype oai_dc
spelling pubmed-45359432015-10-19 Transcriptomic profiling of trichloroethylene exposure in male mouse liver Jiang, Yan Chen, Jiahong Tong, Jian Chen, Tao Data in Brief Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the experimental methods, quality controls, and other information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE58819. Our data provide useful information for gene expression responses to TCE in mouse liver. Elsevier 2015-01-15 /pmc/articles/PMC4535943/ /pubmed/26484163 http://dx.doi.org/10.1016/j.gdata.2015.01.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Jiang, Yan
Chen, Jiahong
Tong, Jian
Chen, Tao
spellingShingle Jiang, Yan
Chen, Jiahong
Tong, Jian
Chen, Tao
Transcriptomic profiling of trichloroethylene exposure in male mouse liver
author_facet Jiang, Yan
Chen, Jiahong
Tong, Jian
Chen, Tao
author_sort Jiang, Yan
title Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_short Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_full Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_fullStr Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_full_unstemmed Transcriptomic profiling of trichloroethylene exposure in male mouse liver
title_sort transcriptomic profiling of trichloroethylene exposure in male mouse liver
description Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the experimental methods, quality controls, and other information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE58819. Our data provide useful information for gene expression responses to TCE in mouse liver.
publisher Elsevier
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535943/
_version_ 1613259476041728000

Similar Items