DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells

The data described in this article pertain to the article by Kuchipudi et al. (2014) titled “Highly Pathogenic Avian Influenza Virus Infection in Chickens But Not Ducks Is Associated with Elevated Host Immune and Pro-inflammatory Responses” [1]. While infection of chickens with highly pathogenic avi...

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Main Authors:	Kuchipudi, Suresh V., Dunham, Stephen P., Chang, Kin-Chow
Format:	Online
Language:	English
Published:	Elsevier 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535746/

id	pubmed-4535746
recordtype	oai_dc
spelling	pubmed-45357462015-10-19 DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells Kuchipudi, Suresh V. Dunham, Stephen P. Chang, Kin-Chow Data in Brief The data described in this article pertain to the article by Kuchipudi et al. (2014) titled “Highly Pathogenic Avian Influenza Virus Infection in Chickens But Not Ducks Is Associated with Elevated Host Immune and Pro-inflammatory Responses” [1]. While infection of chickens with highly pathogenic avian influenza (HPAI) H5N1 virus subtypes often leads to 100% mortality within 1 to 2 days, infection of ducks in contrast causes mild or no clinical signs. The rapid onset of fatal disease in chickens, but with no evidence of severe clinical symptoms in ducks, suggests underlying differences in their innate immune mechanisms. We used Chicken Genechip microarrays (Affymetrix) to analyse the gene expression profiles of primary chicken and duck lung cells infected with a low pathogenic avian influenza (LPAI) H2N3 virus and two HPAI H5N1 virus subtypes to understand the molecular basis of host susceptibility and resistance in chickens and ducks. Here, we described the experimental design, quality control and analysis that were performed on the data set. The data are publicly available through the Gene Expression Omnibus (GEO)database with accession number GSE33389, and the analysis and interpretation of these data are included in Kuchipudi et al. (2014) [1]. Elsevier 2015-03-20 /pmc/articles/PMC4535746/ /pubmed/26484178 http://dx.doi.org/10.1016/j.gdata.2015.03.004 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kuchipudi, Suresh V. Dunham, Stephen P. Chang, Kin-Chow
spellingShingle	Kuchipudi, Suresh V. Dunham, Stephen P. Chang, Kin-Chow DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells
author_facet	Kuchipudi, Suresh V. Dunham, Stephen P. Chang, Kin-Chow
author_sort	Kuchipudi, Suresh V.
title	DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells
title_short	DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells
title_full	DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells
title_fullStr	DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells
title_full_unstemmed	DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells
title_sort	dna microarray global gene expression analysis of influenza virus-infected chicken and duck cells
description	The data described in this article pertain to the article by Kuchipudi et al. (2014) titled “Highly Pathogenic Avian Influenza Virus Infection in Chickens But Not Ducks Is Associated with Elevated Host Immune and Pro-inflammatory Responses” [1]. While infection of chickens with highly pathogenic avian influenza (HPAI) H5N1 virus subtypes often leads to 100% mortality within 1 to 2 days, infection of ducks in contrast causes mild or no clinical signs. The rapid onset of fatal disease in chickens, but with no evidence of severe clinical symptoms in ducks, suggests underlying differences in their innate immune mechanisms. We used Chicken Genechip microarrays (Affymetrix) to analyse the gene expression profiles of primary chicken and duck lung cells infected with a low pathogenic avian influenza (LPAI) H2N3 virus and two HPAI H5N1 virus subtypes to understand the molecular basis of host susceptibility and resistance in chickens and ducks. Here, we described the experimental design, quality control and analysis that were performed on the data set. The data are publicly available through the Gene Expression Omnibus (GEO)database with accession number GSE33389, and the analysis and interpretation of these data are included in Kuchipudi et al. (2014) [1].
publisher	Elsevier
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535746/
_version_	1613259396824956928

DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells

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