Using shRNA experiments to validate gene regulatory networks

Quantitative validation of gene regulatory networks (GRNs) inferred from observational expression data is a difficult task usually involving time intensive and costly laboratory experiments. We were able to show that gene knock-down experiments can be used to quantitatively assess the quality of lar...

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Bibliographic Details
Main Authors: Olsen, Catharina, Fleming, Kathleen, Prendergast, Niall, Rubio, Renee, Emmert-Streib, Frank, Bontempi, Gianluca, Quackenbush, John, Haibe-Kains, Benjamin
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535466/