Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3☆
The four secreted R-spondin (Rspo1-4) proteins of vertebrates function as stem cell growth factors and potentiate canonical Wnt signalling. Rspo proteins act by cross-linking members of two cell surface receptor families, complexing the stem cell markers LGR4-6 with the Frizzled-specific E3 ubiquiti...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Academic Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533229/ |