Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma

A worker with occupational exposure to aluminum powder developed asthmatic symptoms three years and six months after starting work. Skin tests (prick and intradermal) to aluminum chloride (AlCl3) were negative. Inhalation challenge test with 10 mg of aluminum powder and 10 mg/ml of AlCl3 solution in...

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Main Authors:	Park, Hae-Sim, Uh, Soo-Taek, Park, Choon-Sik
Format:	Online
Language:	English
Published:	Korean Association of Internal Medicine 1996
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531999/

id	pubmed-4531999
recordtype	oai_dc
spelling	pubmed-45319992015-10-02 Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma Park, Hae-Sim Uh, Soo-Taek Park, Choon-Sik Original Article A worker with occupational exposure to aluminum powder developed asthmatic symptoms three years and six months after starting work. Skin tests (prick and intradermal) to aluminum chloride (AlCl3) were negative. Inhalation challenge test with 10 mg of aluminum powder and 10 mg/ml of AlCl3 solution induced an early asthmatic response. Sodium cromoglycate pre-treatment reduced AlCl3-induced bronchoconstriction. Neutrophil chemotactic activity was markedly increased one and seven hours after the challenge procedure, which was lessened with sodium cromoglycate pre-treatment. Aluminum can induce occupational asthma in exposed worker, which may be mediated by a non-immunologic mechanism and the possible role of neutrophils was suggested. Korean Association of Internal Medicine 1996-01 /pmc/articles/PMC4531999/ /pubmed/8882478 http://dx.doi.org/10.3904/kjim.1996.11.1.69 Text en Copyright © 1996 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Park, Hae-Sim Uh, Soo-Taek Park, Choon-Sik
spellingShingle	Park, Hae-Sim Uh, Soo-Taek Park, Choon-Sik Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma
author_facet	Park, Hae-Sim Uh, Soo-Taek Park, Choon-Sik
author_sort	Park, Hae-Sim
title	Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma
title_short	Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma
title_full	Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma
title_fullStr	Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma
title_full_unstemmed	Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma
title_sort	increased neutrophil chemotactic activity is noted in alminum-induced occupational asthma
description	A worker with occupational exposure to aluminum powder developed asthmatic symptoms three years and six months after starting work. Skin tests (prick and intradermal) to aluminum chloride (AlCl3) were negative. Inhalation challenge test with 10 mg of aluminum powder and 10 mg/ml of AlCl3 solution induced an early asthmatic response. Sodium cromoglycate pre-treatment reduced AlCl3-induced bronchoconstriction. Neutrophil chemotactic activity was markedly increased one and seven hours after the challenge procedure, which was lessened with sodium cromoglycate pre-treatment. Aluminum can induce occupational asthma in exposed worker, which may be mediated by a non-immunologic mechanism and the possible role of neutrophils was suggested.
publisher	Korean Association of Internal Medicine
publishDate	1996
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531999/
_version_	1613258125326942208

Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma

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