Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy

Lymphocytic hypophysitis is a rare inflammatory disorder in the pituitary gland. The lesion is usually confined to the adenohypophysis. Although the involvement of the posterior pituitary gland or the stalk is rare, such patients with diabetes insipidus have been reported. Surgery has been used to m...

Full description

Bibliographic Details
Main Authors:	Jo, Young-Suk, Lee, Hyo-Jin, Rha, So-Young, Hong, Woo-Jung, Song, Chang-June, Kim, Young-Kun, Ro, Heung-Kyu
Format:	Online
Language:	English
Published:	Korean Association of Internal Medicine 2004
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531567/

id	pubmed-4531567
recordtype	oai_dc
spelling	pubmed-45315672015-10-02 Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy Jo, Young-Suk Lee, Hyo-Jin Rha, So-Young Hong, Woo-Jung Song, Chang-June Kim, Young-Kun Ro, Heung-Kyu Case Report Lymphocytic hypophysitis is a rare inflammatory disorder in the pituitary gland. The lesion is usually confined to the adenohypophysis. Although the involvement of the posterior pituitary gland or the stalk is rare, such patients with diabetes insipidus have been reported. Surgery has been used to make the definitive diagnosis. Recent studies suggest, however, that the pathologic diagnosis may not be necessary always. We reported a case of Lymphocytic hypophysitis managed by methylprednisolone pulse therapy. A 50-year-old premenopausal woman with Lymphocytic hypophysitis and diabetes insipidus was treated with methylprednisolone pulse therapy. Her adenopituitary lesion disappeared and the diabetes insipidus resolved. The optimal management for patients with lymphocytic hypophysitis may be the high index of the suspicion prior to the extensive surgical resection. In addition, methylprednisolone pulse therapy may improve the clinical and MRI findings. Korean Association of Internal Medicine 2004-09 /pmc/articles/PMC4531567/ /pubmed/15481611 http://dx.doi.org/10.3904/kjim.2004.19.3.189 Text en Copyright © 2004 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Jo, Young-Suk Lee, Hyo-Jin Rha, So-Young Hong, Woo-Jung Song, Chang-June Kim, Young-Kun Ro, Heung-Kyu
spellingShingle	Jo, Young-Suk Lee, Hyo-Jin Rha, So-Young Hong, Woo-Jung Song, Chang-June Kim, Young-Kun Ro, Heung-Kyu Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy
author_facet	Jo, Young-Suk Lee, Hyo-Jin Rha, So-Young Hong, Woo-Jung Song, Chang-June Kim, Young-Kun Ro, Heung-Kyu
author_sort	Jo, Young-Suk
title	Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy
title_short	Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy
title_full	Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy
title_fullStr	Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy
title_full_unstemmed	Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy
title_sort	lymphocytic hypophysitis with diabetes insipidus: improvement by methylprednisolone pulse therapy
description	Lymphocytic hypophysitis is a rare inflammatory disorder in the pituitary gland. The lesion is usually confined to the adenohypophysis. Although the involvement of the posterior pituitary gland or the stalk is rare, such patients with diabetes insipidus have been reported. Surgery has been used to make the definitive diagnosis. Recent studies suggest, however, that the pathologic diagnosis may not be necessary always. We reported a case of Lymphocytic hypophysitis managed by methylprednisolone pulse therapy. A 50-year-old premenopausal woman with Lymphocytic hypophysitis and diabetes insipidus was treated with methylprednisolone pulse therapy. Her adenopituitary lesion disappeared and the diabetes insipidus resolved. The optimal management for patients with lymphocytic hypophysitis may be the high index of the suspicion prior to the extensive surgical resection. In addition, methylprednisolone pulse therapy may improve the clinical and MRI findings.
publisher	Korean Association of Internal Medicine
publishDate	2004
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531567/
_version_	1613257892028219392

Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy

Similar Items