Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows

Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly aft...

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Main Authors:	DEVKOTA, Bhuminad, TAKAHASHI, Masahiro, SATO, Saori, SASAKI, Kouya, UEKI, Atsushi, OSAWA, Takeshi, YAMAGISHI, Norio
Format:	Online
Language:	English
Published:	The Japanese Society of Veterinary Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527514/

id	pubmed-4527514
recordtype	oai_dc
spelling	pubmed-45275142015-08-07 Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows DEVKOTA, Bhuminad TAKAHASHI, Masahiro SATO, Saori SASAKI, Kouya UEKI, Atsushi OSAWA, Takeshi TAKAHASHI, Masahiro YAMAGISHI, Norio Internal Medicine Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum. The plasma concentration of carboxyterminal collagen cross-links of type-I collagen (CTx) increased significantly after parturition. These observations suggest that osteoclast-mediated bone resorption was activated after parturition when plasma E2 concentrations decreased. The Japanese Society of Veterinary Science 2015-03-09 2015-07 /pmc/articles/PMC4527514/ /pubmed/25755022 http://dx.doi.org/10.1292/jvms.15-0018 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	DEVKOTA, Bhuminad TAKAHASHI, Masahiro SATO, Saori SASAKI, Kouya UEKI, Atsushi OSAWA, Takeshi TAKAHASHI, Masahiro YAMAGISHI, Norio
spellingShingle	DEVKOTA, Bhuminad TAKAHASHI, Masahiro SATO, Saori SASAKI, Kouya UEKI, Atsushi OSAWA, Takeshi TAKAHASHI, Masahiro YAMAGISHI, Norio Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
author_facet	DEVKOTA, Bhuminad TAKAHASHI, Masahiro SATO, Saori SASAKI, Kouya UEKI, Atsushi OSAWA, Takeshi TAKAHASHI, Masahiro YAMAGISHI, Norio
author_sort	DEVKOTA, Bhuminad
title	Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
title_short	Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
title_full	Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
title_fullStr	Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
title_full_unstemmed	Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
title_sort	plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows
description	Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum. The plasma concentration of carboxyterminal collagen cross-links of type-I collagen (CTx) increased significantly after parturition. These observations suggest that osteoclast-mediated bone resorption was activated after parturition when plasma E2 concentrations decreased.
publisher	The Japanese Society of Veterinary Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527514/
_version_	1613256621698318336

Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows

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