The role of neighboring infected cattle in bovine leukemia virus transmission risk

A cohort study was conducted to evaluate the risk of bovine leukemia virus (BLV) transmission to uninfected cattle by adjacent infected cattle in 6 dairy farms. Animals were initially tested in 2010–2011 using a commercial ELISA kit. Uninfected cattle were repeatedly tested every 4 to 6 months until...

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Main Authors:	KOBAYASHI, Sota, TSUTSUI, Toshiyuki, YAMAMOTO, Takehisa, HAYAMA, Yoko, MUROGA, Norihiko, KONISHI, Misako, KAMEYAMA, Ken-ichiro, MURAKAMI, Kenji
Format:	Online
Language:	English
Published:	The Japanese Society of Veterinary Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527511/

id	pubmed-4527511
recordtype	oai_dc
spelling	pubmed-45275112015-08-07 The role of neighboring infected cattle in bovine leukemia virus transmission risk KOBAYASHI, Sota TSUTSUI, Toshiyuki YAMAMOTO, Takehisa HAYAMA, Yoko MUROGA, Norihiko KONISHI, Misako KAMEYAMA, Ken-ichiro MURAKAMI, Kenji Virology A cohort study was conducted to evaluate the risk of bovine leukemia virus (BLV) transmission to uninfected cattle by adjacent infected cattle in 6 dairy farms. Animals were initially tested in 2010–2011 using a commercial ELISA kit. Uninfected cattle were repeatedly tested every 4 to 6 months until fall of 2012. The Cox proportional hazard model with frailty showed that uninfected cattle neighboring to infected cattle (n=53) had a significant higher risk of seroconversion than those without any infected neighbors (n=81) (hazard ratio: 12.4, P=0.001), implying that neighboring infected cattle were a significant risk factor for BLV transmission. This finding provides scientific support for animal health authorities and farmers to segregate infected cattle on farms to prevent spread of BLV. The Japanese Society of Veterinary Science 2015-03-05 2015-07 /pmc/articles/PMC4527511/ /pubmed/25754652 http://dx.doi.org/10.1292/jvms.15-0007 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	KOBAYASHI, Sota TSUTSUI, Toshiyuki YAMAMOTO, Takehisa HAYAMA, Yoko MUROGA, Norihiko KONISHI, Misako KAMEYAMA, Ken-ichiro MURAKAMI, Kenji
spellingShingle	KOBAYASHI, Sota TSUTSUI, Toshiyuki YAMAMOTO, Takehisa HAYAMA, Yoko MUROGA, Norihiko KONISHI, Misako KAMEYAMA, Ken-ichiro MURAKAMI, Kenji The role of neighboring infected cattle in bovine leukemia virus transmission risk
author_facet	KOBAYASHI, Sota TSUTSUI, Toshiyuki YAMAMOTO, Takehisa HAYAMA, Yoko MUROGA, Norihiko KONISHI, Misako KAMEYAMA, Ken-ichiro MURAKAMI, Kenji
author_sort	KOBAYASHI, Sota
title	The role of neighboring infected cattle in bovine leukemia virus transmission risk
title_short	The role of neighboring infected cattle in bovine leukemia virus transmission risk
title_full	The role of neighboring infected cattle in bovine leukemia virus transmission risk
title_fullStr	The role of neighboring infected cattle in bovine leukemia virus transmission risk
title_full_unstemmed	The role of neighboring infected cattle in bovine leukemia virus transmission risk
title_sort	role of neighboring infected cattle in bovine leukemia virus transmission risk
description	A cohort study was conducted to evaluate the risk of bovine leukemia virus (BLV) transmission to uninfected cattle by adjacent infected cattle in 6 dairy farms. Animals were initially tested in 2010–2011 using a commercial ELISA kit. Uninfected cattle were repeatedly tested every 4 to 6 months until fall of 2012. The Cox proportional hazard model with frailty showed that uninfected cattle neighboring to infected cattle (n=53) had a significant higher risk of seroconversion than those without any infected neighbors (n=81) (hazard ratio: 12.4, P=0.001), implying that neighboring infected cattle were a significant risk factor for BLV transmission. This finding provides scientific support for animal health authorities and farmers to segregate infected cattle on farms to prevent spread of BLV.
publisher	The Japanese Society of Veterinary Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527511/
_version_	1613256618897571840

The role of neighboring infected cattle in bovine leukemia virus transmission risk

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