The Evolutionary Potential of Phenotypic Mutations

Errors in protein synthesis, so-called phenotypic mutations, are orders-of-magnitude more frequent than genetic mutations. Here, we provide direct evidence that alternative protein forms and phenotypic variability derived from translational errors paved the path to genetic, evolutionary adaptations...

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Bibliographic Details
Main Authors: Yanagida, Hayato, Gispan, Ariel, Kadouri, Noam, Rozen, Shelly, Sharon, Michal, Barkai, Naama, Tawfik, Dan S.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526572/