Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation

Adipocytes are the primary cells in adipose tissue, and adipocyte dysfunction causes lipodystrophy, obesity and diabetes. The dipeptidyl peptidase (DPP) 4 family includes four enzymes, DPP4, DPP8, DPP9 and fibroblast activation protein (FAP). DPP4 family inhibitors have been used for the treatment o...

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Bibliographic Details
Main Authors: Han, Ruijun, Wang, Xinying, Bachovchin, William, Zukowska, Zofia, Osborn, John W.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525143/