MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient state promotes MutL homolog recruitment and a...

Full description

Bibliographic Details
Main Authors: Groothuizen, Flora S, Winkler, Ines, Cristóvão, Michele, Fish, Alexander, Winterwerp, Herrie HK, Reumer, Annet, Marx, Andreas D, Hermans, Nicolaas, Nicholls, Robert A, Murshudov, Garib N, Lebbink, Joyce HG, Friedhoff, Peter, Sixma, Titia K
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521584/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521584/

Similar Items