Genetic instability in the tumor microenvironment: a new look at an old neighbor

The recent exponential increase in our knowledge of cellular and molecular mechanisms involved in carcinogenesis has largely failed to translate into new therapies and clinical practices. This lack of success may result in part from the fact that most studies focus on tumor cells as potential therap...

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Main Authors:	Palumbo, Antonio, de Oliveira Meireles Da Costa, Nathalia, Bonamino, Martin Hernan, Ribeiro Pinto, Luis Felipe, Nasciutti, Luiz Eurico
Format:	Online
Language:	English
Published:	BioMed Central 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521350/

id	pubmed-4521350
recordtype	oai_dc
spelling	pubmed-45213502015-08-01 Genetic instability in the tumor microenvironment: a new look at an old neighbor Palumbo, Antonio de Oliveira Meireles Da Costa, Nathalia Bonamino, Martin Hernan Ribeiro Pinto, Luis Felipe Nasciutti, Luiz Eurico Review The recent exponential increase in our knowledge of cellular and molecular mechanisms involved in carcinogenesis has largely failed to translate into new therapies and clinical practices. This lack of success may result in part from the fact that most studies focus on tumor cells as potential therapeutic targets and neglect the complex microenvironment that undergoes profound changes during tumor development. Furthermore, an unfortunate association of factors such as tumor genetic complexity, overestimation of biomarker and drug potentials, as well as a poor understanding of tumor microenvironment in diagnosis and prognosis leads to the current levels of treatment failure regarding a vast majority of cancer types. A growing body of evidence points to the importance of the functional diversity of immune and structural cells during tumor development. In this sense, the lack of technologies that would allow for molecular screening of individual stromal cell types poses a major challenge for the development of therapies targeting the tumor microenvironment. Progress in microenvironment genetic studies represents a formidable opportunity for the development of new selective drugs because stromal cells have lower mutation rates than malignant cells, and should prove to be good targets for therapy. BioMed Central 2015-07-31 /pmc/articles/PMC4521350/ /pubmed/26227631 http://dx.doi.org/10.1186/s12943-015-0409-y Text en © Palumbo et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Palumbo, Antonio de Oliveira Meireles Da Costa, Nathalia Bonamino, Martin Hernan Ribeiro Pinto, Luis Felipe Nasciutti, Luiz Eurico
spellingShingle	Palumbo, Antonio de Oliveira Meireles Da Costa, Nathalia Bonamino, Martin Hernan Ribeiro Pinto, Luis Felipe Nasciutti, Luiz Eurico Genetic instability in the tumor microenvironment: a new look at an old neighbor
author_facet	Palumbo, Antonio de Oliveira Meireles Da Costa, Nathalia Bonamino, Martin Hernan Ribeiro Pinto, Luis Felipe Nasciutti, Luiz Eurico
author_sort	Palumbo, Antonio
title	Genetic instability in the tumor microenvironment: a new look at an old neighbor
title_short	Genetic instability in the tumor microenvironment: a new look at an old neighbor
title_full	Genetic instability in the tumor microenvironment: a new look at an old neighbor
title_fullStr	Genetic instability in the tumor microenvironment: a new look at an old neighbor
title_full_unstemmed	Genetic instability in the tumor microenvironment: a new look at an old neighbor
title_sort	genetic instability in the tumor microenvironment: a new look at an old neighbor
description	The recent exponential increase in our knowledge of cellular and molecular mechanisms involved in carcinogenesis has largely failed to translate into new therapies and clinical practices. This lack of success may result in part from the fact that most studies focus on tumor cells as potential therapeutic targets and neglect the complex microenvironment that undergoes profound changes during tumor development. Furthermore, an unfortunate association of factors such as tumor genetic complexity, overestimation of biomarker and drug potentials, as well as a poor understanding of tumor microenvironment in diagnosis and prognosis leads to the current levels of treatment failure regarding a vast majority of cancer types. A growing body of evidence points to the importance of the functional diversity of immune and structural cells during tumor development. In this sense, the lack of technologies that would allow for molecular screening of individual stromal cell types poses a major challenge for the development of therapies targeting the tumor microenvironment. Progress in microenvironment genetic studies represents a formidable opportunity for the development of new selective drugs because stromal cells have lower mutation rates than malignant cells, and should prove to be good targets for therapy.
publisher	BioMed Central
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521350/
_version_	1613254599876018176

Genetic instability in the tumor microenvironment: a new look at an old neighbor

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