Targeting the adaptive molecular landscape of castration-resistant prostate cancer

Castration and androgen receptor (AR) pathway inhibitors induce profound and sustained responses in advanced prostate cancer. However, the inevitable recurrence is associated with reactivation of the AR and progression to a more aggressive phenotype termed castration-resistant prostate cancer (CRPC)...

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Bibliographic Details
Main Authors: Wyatt, Alexander W, Gleave, Martin E
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520654/