Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

Although anti-retroviral therapy (ART) is highly effective in suppressing HIV replication, it fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are rapidly established early after HIV infection. Therefore, effective strategies for eradication of the HIV reservo...

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Bibliographic Details
Main Authors: Jiang, Guochun, Mendes, Erica A., Kaiser, Philipp, Wong, Daniel P., Tang, Yuyang, Cai, Ivy, Fenton, Anne, Melcher, Gregory P., Hildreth, James E. K., Thompson, George R., Wong, Joseph K., Dandekar, Satya
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520526/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520526/

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