Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation

Raman spectroscopy has emerged as a promising tool for real-time clinical diagnosis of malignant skin tumors offering a number of potential advantages: it is non-intrusive, it requires no sample preparation, and it features high chemical specificity with minimal water interference. However, in vivo...

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Main Authors:	Kourkoumelis, Nikolaos, Balatsoukas, Ioannis, Moulia, Violetta, Elka, Aspasia, Gaitanis, Georgios, Bassukas, Ioannis D.
Format:	Online
Language:	English
Published:	MDPI 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519858/

id	pubmed-4519858
recordtype	oai_dc
spelling	pubmed-45198582015-08-03 Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation Kourkoumelis, Nikolaos Balatsoukas, Ioannis Moulia, Violetta Elka, Aspasia Gaitanis, Georgios Bassukas, Ioannis D. Review Raman spectroscopy has emerged as a promising tool for real-time clinical diagnosis of malignant skin tumors offering a number of potential advantages: it is non-intrusive, it requires no sample preparation, and it features high chemical specificity with minimal water interference. However, in vivo tissue evaluation and accurate histopathological classification remain a challenging task for the successful transition from laboratory prototypes to clinical devices. In the literature, there are numerous reports on the applications of Raman spectroscopy to biomedical research and cancer diagnostics. Nevertheless, cases where real-time, portable instrumentations have been employed for the in vivo evaluation of skin lesions are scarce, despite their advantages in use as medical devices in the clinical setting. This paper reviews the advances in real-time Raman spectroscopy for the in vivo characterization of common skin lesions. The translational momentum of Raman spectroscopy towards the clinical practice is revealed by (i) assembling the technical specifications of portable systems and (ii) analyzing the spectral characteristics of in vivo measurements. MDPI 2015-06-26 /pmc/articles/PMC4519858/ /pubmed/26132563 http://dx.doi.org/10.3390/ijms160714554 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kourkoumelis, Nikolaos Balatsoukas, Ioannis Moulia, Violetta Elka, Aspasia Gaitanis, Georgios Bassukas, Ioannis D.
spellingShingle	Kourkoumelis, Nikolaos Balatsoukas, Ioannis Moulia, Violetta Elka, Aspasia Gaitanis, Georgios Bassukas, Ioannis D. Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation
author_facet	Kourkoumelis, Nikolaos Balatsoukas, Ioannis Moulia, Violetta Elka, Aspasia Gaitanis, Georgios Bassukas, Ioannis D.
author_sort	Kourkoumelis, Nikolaos
title	Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation
title_short	Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation
title_full	Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation
title_fullStr	Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation
title_full_unstemmed	Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation
title_sort	advances in the in vivo raman spectroscopy of malignant skin tumors using portable instrumentation
description	Raman spectroscopy has emerged as a promising tool for real-time clinical diagnosis of malignant skin tumors offering a number of potential advantages: it is non-intrusive, it requires no sample preparation, and it features high chemical specificity with minimal water interference. However, in vivo tissue evaluation and accurate histopathological classification remain a challenging task for the successful transition from laboratory prototypes to clinical devices. In the literature, there are numerous reports on the applications of Raman spectroscopy to biomedical research and cancer diagnostics. Nevertheless, cases where real-time, portable instrumentations have been employed for the in vivo evaluation of skin lesions are scarce, despite their advantages in use as medical devices in the clinical setting. This paper reviews the advances in real-time Raman spectroscopy for the in vivo characterization of common skin lesions. The translational momentum of Raman spectroscopy towards the clinical practice is revealed by (i) assembling the technical specifications of portable systems and (ii) analyzing the spectral characteristics of in vivo measurements.
publisher	MDPI
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519858/
_version_	1613253989172772864

Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation

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