Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Physiological responses to CR are cell-type specific and variable throughout the lifespan. However, the mosaic of molecular changes responsible for CR benefits remains unclear, particularly in brain regio...

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Bibliographic Details
Main Authors: Schafer, Marissa J., Dolgalev, Igor, Alldred, Melissa J., Heguy, Adriana, Ginsberg, Stephen D.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519125/