Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination

Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes strand exchange with homologous duplex DNA. BRCA2 and the Rad51 paralogs are tumor suppressors and critical mediators of Rad51. To gain insigh...

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Bibliographic Details
Main Authors: Taylor, Martin R.G., Špírek, Mário, Chaurasiya, Kathy R., Ward, Jordan D., Carzaniga, Raffaella, Yu, Xiong, Egelman, Edward H., Collinson, Lucy M., Rueda, David, Krejci, Lumir, Boulton, Simon J.
Format: Online
Language:English
Published: Cell Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518479/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518479/

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