Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived reactive oxygen species, confers host defense against a broad spectrum of bacterial and fungal pathogens. Loss-of-function mutations that impair function of the Nox2 complex result in a life-threatening immunodeficiency, and genet...

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Bibliographic Details
Main Authors: Graham, Daniel B., Becker, Christine E., Doan, Aivi, Goel, Gautam, Villablanca, Eduardo J., Knights, Dan, Mok, Amanda, Ng, Aylwin C.Y., Doench, John G., Root, David E., Clish, Clary B., Xavier, Ramnik J.
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518307/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518307/

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