Akt mediates 17β-estradiol and/or estrogen receptor-α inhibition of LPS-induced tumor necresis factor-α expression and myocardial cell apoptosis by suppressing the JNK1/2-NFκB pathway

Akt mediates 17β-estradiol and/or estrogen receptor-α inhibition of LPS-induced tumor necresis factor-α expression and myocardial cell apoptosis by suppressing the JNK1/2-NFκB pathway

Evidence shows that women have lower tumour necrosis factor-α (TNF-α) levels and lower incidences of heart dysfunction and sepsis-related morbidity and mortality. To identify the cardioprotective effects and precise cellular/molecular mechanisms behind estrogen and estrogen receptors (ERs), we inves...

Full description

Bibliographic Details
Main Authors: Liu, Chung-Jung, Lo, Jeng-Fan, Kuo, Chia-Hua, Chu, Chun-Hsien, Chen, Li-Ming, Tsai, Fuu-Jen, Tsai, Chang-Hai, Tzang, Bor-Show, Kuo, Wei-Wen, Huang, Chih-Yang
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516514/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516514/

Similar Items