Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures
Disuse-induced skeletal muscle atrophy occurs following chronic periods of inactivity such as those involving prolonged bed rest, trauma and microgravity environments. Deconditioning of skeletal muscle is mainly characterized by a loss of muscle mass, decreased fibre cross-sectional area, reduced fo...
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| Format: | Online |
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John Wiley & Sons, Ltd
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516463/ |
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pubmed-4516463 |
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pubmed-45164632015-08-03 Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures Chopard, Angèle Hillock, Steven Jasmin, Bernard J Reviews Disuse-induced skeletal muscle atrophy occurs following chronic periods of inactivity such as those involving prolonged bed rest, trauma and microgravity environments. Deconditioning of skeletal muscle is mainly characterized by a loss of muscle mass, decreased fibre cross-sectional area, reduced force, increased fatigability, increased insulin resistance and transitions in fibre types. A description of the role of specific transcriptional mechanisms contributing to muscle atrophy by altering gene expression during muscle disuse has recently emerged and focused primarily on short period of inactivity. A better understanding of the transduction pathways involved in activation of proteolytic and apoptotic pathways continues to represent a major objective, together with the study of potential cross-talks in these cellular events. In parallel, evaluation of the impact of countermeasures at the cellular and molecular levels in short- and long-term disuse experimentations or microgravity environments should undoubtedly and synergistically increase our basic knowledge in attempts to identify new physical, pharmacological and nutritional targets to counteract muscle atrophy. These investigations are important as skeletal muscle atrophy remains an important neuromuscular challenge with impact in clinical and social settings affecting a variety of conditions such as those seen in aging, cancer cachexia, muscle pathologies and long-term space exploration. John Wiley & Sons, Ltd 2009-09 2009-07-28 /pmc/articles/PMC4516463/ /pubmed/19656243 http://dx.doi.org/10.1111/j.1582-4934.2009.00864.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chopard, Angèle Hillock, Steven Jasmin, Bernard J |
| spellingShingle |
Chopard, Angèle Hillock, Steven Jasmin, Bernard J Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| author_facet |
Chopard, Angèle Hillock, Steven Jasmin, Bernard J |
| author_sort |
Chopard, Angèle |
| title |
Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| title_short |
Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| title_full |
Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| title_fullStr |
Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| title_full_unstemmed |
Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| title_sort |
molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| description |
Disuse-induced skeletal muscle atrophy occurs following chronic periods of inactivity such as those involving prolonged bed rest, trauma and microgravity environments. Deconditioning of skeletal muscle is mainly characterized by a loss of muscle mass, decreased fibre cross-sectional area, reduced force, increased fatigability, increased insulin resistance and transitions in fibre types. A description of the role of specific transcriptional mechanisms contributing to muscle atrophy by altering gene expression during muscle disuse has recently emerged and focused primarily on short period of inactivity. A better understanding of the transduction pathways involved in activation of proteolytic and apoptotic pathways continues to represent a major objective, together with the study of potential cross-talks in these cellular events. In parallel, evaluation of the impact of countermeasures at the cellular and molecular levels in short- and long-term disuse experimentations or microgravity environments should undoubtedly and synergistically increase our basic knowledge in attempts to identify new physical, pharmacological and nutritional targets to counteract muscle atrophy. These investigations are important as skeletal muscle atrophy remains an important neuromuscular challenge with impact in clinical and social settings affecting a variety of conditions such as those seen in aging, cancer cachexia, muscle pathologies and long-term space exploration. |
| publisher |
John Wiley & Sons, Ltd |
| publishDate |
2009 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516463/ |
| _version_ |
1613252712673050624 |