Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival

Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival

Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high...

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Main Authors: O'Sullivan, K. E., Hurley, E. T., Hurley, J. P.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515501/
id pubmed-4515501
recordtype oai_dc
spelling pubmed-45155012015-08-05 Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival O'Sullivan, K. E. Hurley, E. T. Hurley, J. P. Review Article Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards definitive chemoradiotherapy for a number of tumour sites (head and neck, cervical, and rectal) particularly for squamous pathology. We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic. Hindawi Publishing Corporation 2015 2015-07-13 /pmc/articles/PMC4515501/ /pubmed/26246803 http://dx.doi.org/10.1155/2015/518281 Text en Copyright © 2015 K. E. O'Sullivan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author O'Sullivan, K. E.
Hurley, E. T.
Hurley, J. P.
spellingShingle O'Sullivan, K. E.
Hurley, E. T.
Hurley, J. P.
Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
author_facet O'Sullivan, K. E.
Hurley, E. T.
Hurley, J. P.
author_sort O'Sullivan, K. E.
title Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_short Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_full Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_fullStr Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_full_unstemmed Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_sort understanding complete pathologic response in oesophageal cancer: implications for management and survival
description Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards definitive chemoradiotherapy for a number of tumour sites (head and neck, cervical, and rectal) particularly for squamous pathology. We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic.
publisher Hindawi Publishing Corporation
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515501/
_version_ 1613252329797058560

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