Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in the h...

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Main Authors: Tsai, Vicky Wang-Wei, Macia, Laurence, Feinle-Bisset, Christine, Manandhar, Rakesh, Astrup, Arne, Raben, Anne, Lorenzen, Janne Kunchel, Schmidt, Peter T., Wiklund, Fredrik, Pedersen, Nancy L., Campbell, Lesley, Kriketos, Adamandia, Xu, Aimin, Pengcheng, Zhou, Jia, Weiping, Curmi, Paul M G., Angstmann, Christopher N., Lee-Ng, Ka Ki Michelle, Zhang, Hong Ping, Marquis, Christopher P., Husaini, Yasmin, Beglinger, Christoph, Lin, Shu, Herzog, Herbert, Brown, David A., Sainsbury, Amanda, Breit, Samuel N.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514813/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514813/

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