RNA interference-mediated silencing of the polo-like kinase 1 gene enhances chemosensitivity to gemcitabine in pancreatic adenocarcinoma cells

RNA interference-mediated silencing of the polo-like kinase 1 gene enhances chemosensitivity to gemcitabine in pancreatic adenocarcinoma cells

Gemcitabine is the first-line chemotherapeutic agent for advanced adenocarcinoma of the pancreas; however, chemoresistance to gemcitabine remains a major cause of failure for the clinical treatment of this disease. Polo-like kinase 1 (Plk-1) is highly expressed in pancreatic cancer cell lines and pa...

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Bibliographic Details
Main Authors: Yu, C, Zhang, X, Sun, G, Guo, X, Li, H, You, Y, Jacobs, J L, Gardner, K, Yuan, D, Xu, Z, Du, Q, Dai, C, Qian, Z, Jiang, K, Zhu, Y, Li, Q Q, Miao, Y
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2008
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514112/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514112/

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