Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia
Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. Here we show, in 2 populations from Burkina Faso (2007–2008), that HbS is associated with a 70% re...
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| Format: | Online |
| Language: | English |
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Oxford University Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512610/ |
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pubmed-45126102015-07-27 Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia Mangano, Valentina D. Kabore, Youssouf Bougouma, Edith C. Verra, Federica Sepulveda, Nuno Bisseye, Cyrille Santolamazza, Federica Avellino, Pamela Tiono, Alfred B. Diarra, Amidou Nebie, Issa Rockett, Kirk A. Sirima, Sodiomon B. Modiano, David Major Articles and Brief Reports Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. Here we show, in 2 populations from Burkina Faso (2007–2008), that HbS is associated with a 70% reduction of harboring P. falciparum parasitemia at the heterozygous state (odds ratio [OR] for AS vs AA, 0.27; 95% confidence interval [CI], .11–.66; P = .004). There is no evidence of protection for HbC in the heterozygous state (OR for AC vs AA, 1.49; 95% CI, .69–3.21; P = .31), whereas protection even higher than that observed with AS is observed in the homozygous and double heterozygous states (OR for CC + SC vs AA, 0.04; 95% CI, .01–.29; P = .002). The abnormal display of parasite-adhesive molecules on the surface of HbS and HbC infected erythrocytes, disrupting the pathogenic process of sequestration, might displace the parasite from the deep to the peripheral circulation, promoting its elimination at the spleen level. Oxford University Press 2015-08-15 2015-02-23 /pmc/articles/PMC4512610/ /pubmed/25712976 http://dx.doi.org/10.1093/infdis/jiv098 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mangano, Valentina D. Kabore, Youssouf Bougouma, Edith C. Verra, Federica Sepulveda, Nuno Bisseye, Cyrille Santolamazza, Federica Avellino, Pamela Tiono, Alfred B. Diarra, Amidou Nebie, Issa Rockett, Kirk A. Sirima, Sodiomon B. Modiano, David |
| spellingShingle |
Mangano, Valentina D. Kabore, Youssouf Bougouma, Edith C. Verra, Federica Sepulveda, Nuno Bisseye, Cyrille Santolamazza, Federica Avellino, Pamela Tiono, Alfred B. Diarra, Amidou Nebie, Issa Rockett, Kirk A. Sirima, Sodiomon B. Modiano, David Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia |
| author_facet |
Mangano, Valentina D. Kabore, Youssouf Bougouma, Edith C. Verra, Federica Sepulveda, Nuno Bisseye, Cyrille Santolamazza, Federica Avellino, Pamela Tiono, Alfred B. Diarra, Amidou Nebie, Issa Rockett, Kirk A. Sirima, Sodiomon B. Modiano, David |
| author_sort |
Mangano, Valentina D. |
| title |
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia |
| title_short |
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia |
| title_full |
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia |
| title_fullStr |
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia |
| title_full_unstemmed |
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia |
| title_sort |
novel insights into the protective role of hemoglobin s and c against plasmodium falciparum parasitemia |
| description |
Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. Here we show, in 2 populations from Burkina Faso (2007–2008), that HbS is associated with a 70% reduction of harboring P. falciparum parasitemia at the heterozygous state (odds ratio [OR] for AS vs AA, 0.27; 95% confidence interval [CI], .11–.66; P = .004). There is no evidence of protection for HbC in the heterozygous state (OR for AC vs AA, 1.49; 95% CI, .69–3.21; P = .31), whereas protection even higher than that observed with AS is observed in the homozygous and double heterozygous states (OR for CC + SC vs AA, 0.04; 95% CI, .01–.29; P = .002). The abnormal display of parasite-adhesive molecules on the surface of HbS and HbC infected erythrocytes, disrupting the pathogenic process of sequestration, might displace the parasite from the deep to the peripheral circulation, promoting its elimination at the spleen level. |
| publisher |
Oxford University Press |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512610/ |
| _version_ |
1613251355551465472 |