Compaction of rolling circle amplification products increases signal integrity and signal-to-noise ratio

Compaction of rolling circle amplification products increases signal integrity and signal-to-noise ratio

Rolling circle amplification (RCA) for generation of distinct fluorescent signals in situ relies upon the self-collapsing properties of single-stranded DNA in commonly used RCA-based methods. By introducing a cross-hybridizing DNA oligonucleotide during rolling circle amplification, we demonstrate t...

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Bibliographic Details
Main Authors: Clausson, Carl-Magnus, Arngården, Linda, Ishaq, Omer, Klaesson, Axel, Kühnemund, Malte, Grannas, Karin, Koos, Björn, Qian, Xiaoyan, Ranefall, Petter, Krzywkowski, Tomasz, Brismar, Hjalmar, Nilsson, Mats, Wählby, Carolina, Söderberg, Ola
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511876/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511876/

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