Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

Enhanced DNA damage repair is one mechanism involved in colon cancer drug resistance. Thus, targeting molecular components of repair pathways with specific small molecule inhibitors may improve the efficacy of chemotherapy. ABT-888 and VE-821, inhibitors of poly-ADP-ribose-polymerase (PARP) and the...

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Bibliographic Details
Main Authors: Abu-Sanad, Atlal, Wang, Yunzhe, Hasheminasab, Fatemeh, Panasci, Justin, Noë, Alycia, Rosca, Lorena, Davidson, David, Amrein, Lilian, Sharif-Askari, Bahram, Aloyz, Raquel, Panasci, Lawrence
Format: Online
Language:English
Published: Frontiers Media S.A. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510998/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510998/

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