Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA

Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA

Pseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouse Oct4 pseudogenes and demonstrate that the X-linked Oct4 pseudogene Oct4P4 critically impacts mouse embryonic stem cells (mESCs) self-renewal. Sense Oct4P4 transcri...

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Bibliographic Details
Main Authors: Scarola, Michele, Comisso, Elisa, Pascolo, Rhena, Chiaradia, Riccardo, Maria Marion, Rosa, Schneider, Claudio, Blasco, Maria A., Schoeftner, Stefan, Benetti, Roberta
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510692/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510692/

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